Coenzyme Q10 (CoQ10) is produced by the human body and is necessary for the basic functioning of cells. Coenzyme Q1 (CoQ1 or NADH) is a natural substance found in most life forms and is necessary for energy production. CoQ10 and NADH are the key members of the electron transfer chain in mitochondria. The passage of electrons along the electron transport chain is coupled to the formation of ATP by the process known as oxidative phosphorylation. Coenzyme Q-10 is not an antioxidant although it is characterized as such in all of the commercial available products. Co-enzyme Q-10 is the oxidized form of this substance and an oxidant can never ever be an antioxidant. However, when CoQ10 is absorbed into the organism it is reduced by NADH and, thus, becomes an antioxidant. In other words, NADH makes Coenzyme Q-10 in the body into an antioxidant; hence, Coenzyme Q-10 needs NADH to become effective. Additionally, CoQ10 concentrations may be increased with NADH supplements.

Coenzyme Q10 deficiency: CoQ10 levels are reported to decrease with age and to be low in patients with some chronic diseases such as heart conditions, muscular dystrophies, Parkinson's disease, cancer, diabetes, and HIV/AIDS. Coenzyme Q10 is normally produced by the human body, although deficiency may occur in patients with impaired CoQ10 biosynthesis due to severe metabolic or mitochondrial disorders, not enough dietary CoQ10 intake, or too much CoQ10 use by the body. Depending on the cause of CoQ10 deficiency, supplementation or increased dietary intake of CoQ10 and the vitamins and minerals needed to produce CoQ10 may be effective.

Evidences for application CoQ10 and/or CoQ1 supplements:

• Heart attack: There is preliminary human study of CoQ10 given to patients within three days after a heart attack. The application of CoQ10 was helpful for the patients.
• High blood pressure: Preliminary research suggests that CoQ10 causes decreases in blood pressure.
• Angina: Preliminary human studies suggest that CoQ10 may reduce angina and improve exercise tolerance in people with clogged heart arteries.
• Age-related macular degeneration: Early study shows that acetyl-L-carnitine, n-3 fatty acids, and Coenzyme Q10 may help age-related macular degeneration.
• Alzheimer's disease: Promising preliminary evidence suggests that CoQ10 and/or CoQ1 supplements may slow down dementia in people with Alzheimer's disease.
• Parkinson's disease: There is promising human evidence for the use of CoQ10 and/or CoQ1 in the treatment of Parkinson's disease.
• Anthracycline chemotherapy heart toxicity: Anthracycline chemotherapy drugs, such as doxorubicin, are commonly used to treat cancers such as breast cancer or lymphoma. Heart damage is a major concern with the use of anthracyclines, and CoQ10 has been suggested to protect the heart.
• Chronic fatigue syndrome: Early study shows that CoQ10 and/or CoQ1 improve symptoms of chronic fatigue syndrome.
• Mitochondrial diseases: CoQ10 and/or CoQ1 is often recommended for patients with mitochondrial diseases, including myopathies, and encephalomyopathies. CoQ10 may help improve function in children with maternally-inherited diabetes and deafness.
• Muscular dystrophies: Preliminary studies in patients with muscular dystrophy taking CoQ10 supplements describe improvements in exercise capacity, heart function, and overall quality of life.
• Type-2 diabetes: CoQ10 may lower blood sugar levels.

Problems for application: Prior to recent discoveries NADH is rather unstable and, hence, not capable of being absorbed by the intestines of the human body. It would have been expected that this substance would be hydrolized in the gastric juice within a few seconds. Formula for treatment: The previously described problem is the cause why the sublingual spray form of NADH was chosen to maximize the absorption and optimize bioavailability of the CoQ1.

Composition of spray: CoenzimQ10; CoenzimQ1; xilit; Oenothera biennis; grapefruit seed extract. Dosing: The below doses are based on scientific research, publications, traditional use, or expert opinion. Adults (above 18 years old): Usually 2x2 puff daily. Children (under 18 years old): There is not enough scientific information to recommend the safe use of CoQ10 in children. A qualified healthcare provider should be consulted before considering use.

Allergies: In theory, allergic reactions to supplements containing CoQ10 may occur. Itching or rash has been reported. Side Effects and Warnings: There are few serious reported side effects of CoQ10. Side effects are typically mild and brief, stopping without any treatment needed. Reactions may include nausea, vomiting, stomach upset, heartburn, diarrhea, loss of appetite, skin itching, rash, insomnia, headache, dizziness, itching, irritability, increased light sensitivity of the eyes, fatigue, or flu-like symptoms. There is not enough scientific evidence to support the safe use of CoQ10 during pregnancy or breastfeeding. Sperm may be affected.